TDRD7

Protein-coding gene in the species Homo sapiens
TDRD7
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3RCO

Identifiers
AliasesTDRD7, CATC4, CTRCT36, PCTAIRE2BP, TRAP, tudor domain containing 7
External IDsOMIM: 611258; MGI: 2140279; HomoloGene: 8618; GeneCards: TDRD7; OMA:TDRD7 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for TDRD7
Genomic location for TDRD7
Band9q22.33Start97,412,096 bp[1]
End97,496,125 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for TDRD7
Genomic location for TDRD7
Band4|4 B1Start45,965,334 bp[2]
End46,034,761 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • jejunal mucosa

  • retinal pigment epithelium

  • internal globus pallidus

  • sperm

  • pars reticulata

  • monocyte

  • duodenum

  • testicle

  • middle frontal gyrus
Top expressed in
  • epithelium of lens

  • spermatid

  • neural layer of retina

  • seminiferous tubule

  • spermatocyte

  • retinal pigment epithelium

  • granulocyte

  • mucous cell of stomach

  • intestinal villus

  • jejunum
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • mRNA binding
  • protein binding
  • protein N-terminus binding
  • RNA binding
Cellular component
  • cytoplasm
  • chromatoid body
  • mitochondrial matrix
  • ribonucleoprotein granule
Biological process
  • posttranscriptional regulation of gene expression
  • cell differentiation
  • lens fiber cell differentiation
  • lens morphogenesis in camera-type eye
  • spermatogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23424

100121

Ensembl

ENSG00000196116

ENSMUSG00000035517

UniProt

Q8NHU6

Q8K1H1

RefSeq (mRNA)

NM_001302884
NM_014290

NM_001290475
NM_146142
NM_001355189

RefSeq (protein)

NP_001289813
NP_055105

NP_001277404
NP_666254
NP_001342118

Location (UCSC)Chr 9: 97.41 – 97.5 MbChr 4: 45.97 – 46.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tudor domain-containing protein 7 is a protein that in humans is encoded by the TDRD7 gene.[5][6]

In melanocytic cells TDRD7 gene expression may be regulated by MITF.[7]

Gene polymorphism

Various single nucleotide polymorphisms (SNPs) of the TDRD7 gene have been identified and for some of them an association with lower susceptibility to age-related cataract was shown.[8]

Interactions

TDRD7 has been shown to interact with TACC1.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196116 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035517 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  6. ^ "Entrez Gene: TDRD7 tudor domain containing 7".
  7. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
  8. ^ Zheng C, Wu M, He CY, An XJ, Sun M, Chen CL, Ye J (Feb 2014). "RNA granule component TDRD7 gene polymorphisms in a Han Chinese population with age-related cataract". J. Int. Med. Res. 42 (1): 153–63. doi:10.1177/0300060513504702. PMID 24435515.
  9. ^ Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251. S2CID 10536264.

Further reading

  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251. S2CID 10536264.
  • Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH (2002). "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells". Biochem. J. 363 (Pt 1): 195–200. doi:10.1042/0264-6021:3630195. PMC 1222467. PMID 11903063.
  • Yamochi T, Nishimoto I, Okuda T, Matsuoka M (2001). "ik3-1/Cables is associated with Trap and Pctaire2". Biochem. Biophys. Res. Commun. 286 (5): 1045–50. doi:10.1006/bbrc.2001.5493. PMID 11527406.
  • Hirose T, Kawabuchi M, Tamaru T, Okumura N, Nagai K, Okada M (2000). "Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain". Eur. J. Biochem. 267 (7): 2113–21. doi:10.1046/j.1432-1327.2000.01218.x. PMID 10727952.

External links

  • Overview of all the structural information available in the PDB for UniProt: Q8NHU6 (Human Tudor domain-containing protein 7) at the PDBe-KB.
  • Overview of all the structural information available in the PDB for UniProt: Q8K1H1 (Mouse Tudor domain-containing protein 7) at the PDBe-KB.
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