TDRD3

Protein-coding gene in the species Homo sapiens
TDRD3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1WJI, 2LTO, 3PMT, 3PNW, 3S6W

Identifiers
AliasesTDRD3, tudor domain containing 3
External IDsOMIM: 614392; MGI: 2444023; HomoloGene: 12771; GeneCards: TDRD3; OMA:TDRD3 - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for TDRD3
Genomic location for TDRD3
Band13q21.2Start60,396,457 bp[1]
End60,573,878 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for TDRD3
Genomic location for TDRD3
Band14|14 E1Start87,654,075 bp[2]
End87,782,940 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • ventricular zone

  • epithelium of colon

  • tendon of biceps brachii

  • gastrocnemius muscle

  • muscle of thigh

  • ganglionic eminence

  • sural nerve

  • body of pancreas

  • corpus callosum
Top expressed in
  • zygote

  • genital tubercle

  • primary oocyte

  • medial ganglionic eminence

  • spermatocyte

  • interventricular septum

  • tail of embryo

  • spermatid

  • Rostral migratory stream

  • Epithelium of choroid plexus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • methylated histone binding
  • transcription coactivator activity
  • chromatin binding
  • protein binding
  • RNA binding
Cellular component
  • cytoplasm
  • exon-exon junction complex
  • nucleus
  • nucleoplasm
  • Golgi apparatus
  • cytosol
Biological process
  • regulation of nucleic acid-templated transcription
  • chromatin organization
  • positive regulation of nucleic acid-templated transcription
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

81550

219249

Ensembl

ENSG00000083544

ENSMUSG00000022019

UniProt

Q9H7E2

Q91W18

RefSeq (mRNA)

NM_001146070
NM_001146071
NM_030794

NM_001253755
NM_172605

RefSeq (protein)

NP_001139542
NP_001139543
NP_110421

NP_001240684
NP_766193

Location (UCSC)Chr 13: 60.4 – 60.57 MbChr 14: 87.65 – 87.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tudor domain-containing protein 3 is a protein that in humans is encoded by the TDRD3 gene.[5] It contains a Tudor domain and UBA protein domain and has three distinct Protein isoforms.


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000083544 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022019 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: TDRD3 tudor domain containing 3".

Further reading

  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
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  • 1wji: Solution Structure of the UBA Domain of Human Tudor Domain Containing Protein 3
    1wji: Solution Structure of the UBA Domain of Human Tudor Domain Containing Protein 3


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