TC2N

Protein-coding gene in the species Homo sapiens
TC2N
Identifiers
AliasesTC2N, C14orf47, C2CD1, MTAC2D1, Tac2-N, tandem C2 domains, nuclear, TAC2N
External IDsMGI: 1921663; HomoloGene: 12560; GeneCards: TC2N; OMA:TC2N - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for TC2N
Genomic location for TC2N
Band14q32.12Start91,779,746 bp[1]
End91,867,536 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for TC2N
Genomic location for TC2N
Band12|12 EStart101,611,702 bp[2]
End101,684,782 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • tonsil

  • olfactory zone of nasal mucosa

  • gallbladder

  • Descending thoracic aorta

  • ascending aorta

  • islet of Langerhans

  • epithelium of colon

  • salivary gland

  • minor salivary glands
Top expressed in
  • seminal vesicula

  • parotid gland

  • lacrimal gland

  • epithelium of stomach

  • retinal pigment epithelium

  • Epithelium of choroid plexus

  • submandibular gland

  • transitional epithelium of urinary bladder

  • left lung lobe

  • olfactory epithelium
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • clathrin binding
  • calcium ion binding
  • syntaxin binding
  • molecular function
  • calcium-dependent phospholipid binding
Cellular component
  • nucleus
  • plasma membrane
  • cellular component
  • synapse
  • presynapse
Biological process
  • vesicle fusion
  • calcium ion-regulated exocytosis of neurotransmitter
  • regulation of calcium ion-dependent exocytosis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

123036

74413

Ensembl

ENSG00000276776
ENSG00000165929

ENSMUSG00000021187

UniProt

Q8N9U0

Q91XT6

RefSeq (mRNA)

NM_152332
NM_001128595
NM_001128596
NM_001289134

NM_001082976
NM_001286364
NM_028924

RefSeq (protein)

NP_001122067
NP_001122068
NP_001276063
NP_689545

NP_001076445
NP_083200

Location (UCSC)Chr 14: 91.78 – 91.87 MbChr 12: 101.61 – 101.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tandem C2 domains nuclear protein is a protein that in humans is encoded by the TC2N gene.[5][6]


References

  1. ^ a b c ENSG00000165929 GRCh38: Ensembl release 89: ENSG00000276776, ENSG00000165929 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021187 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fukuda M, Mikoshiba K (Aug 2001). "Tac2-N, an atypical C-type tandem C2 protein localized in the nucleus". FEBS Lett. 503 (2–3): 217–218. doi:10.1016/S0014-5793(01)02738-7. PMID 11526914. S2CID 33045301.
  6. ^ "Entrez Gene: MTAC2D1 membrane targeting (tandem) C2 domain containing 1".

Further reading

  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.


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