Peptide transporter 1

Mammalian protein found in Homo sapiens

SLC15A1

Identifiers

Aliases

SLC15A1, HPECT1, HPEPT1, PEPT1, Peptide transporter 1, solute carrier family 15 member 1

External IDs

OMIM: 600544; MGI: 1861376; HomoloGene: 38006; GeneCards: SLC15A1; OMA:SLC15A1 - orthologs

Gene location (Human)

Chr.	Chromosome 13 (human)^[1]

Band	13q32.2-q32.3	Start	98,683,801 bp^[1]
Band	13q32.2-q32.3	End	98,752,672 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)^[2]

Band	14\|14 E5	Start	121,697,033 bp^[2]
Band	14\|14 E5	End	121,742,664 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

duodenum

jejunal mucosa

gallbladder

vulva

skin of abdomen

right lobe of liver

human penis

body of pancreas

islet of Langerhans

frontal pole

Top expressed in

intestinal villus

jejunum

left colon

duodenum

ileum

esophagus

skin of back

skin of abdomen

yolk sac

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	proton-dependent oligopeptide secondary active transmembrane transporter activity symporter activity transporter activity transmembrane transporter activity oligopeptide transmembrane transporter activity peptide:proton symporter activity dipeptide transmembrane transporter activity peptide transmembrane transporter activity
Cellular component	integral component of membrane plasma membrane brush border membrane integral component of plasma membrane
Biological process	protein transport peptide transport oligopeptide transport oligopeptide transmembrane transport ion transport transmembrane transport proton transmembrane transport dipeptide transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6564


56643

Ensembl


ENSG00000088386


ENSMUSG00000025557

UniProt


P46059


Q9JIP7

RefSeq (mRNA)


NM_005073


NM_053079

RefSeq (protein)


NP_005064


NP_444309

Location (UCSC)

Chr 13: 98.68 – 98.75 Mb

Chr 14: 121.7 – 121.74 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

PepT 1 is a proton-coupled peptide cotransporter in epithelial cells.

Peptide transporter 1 (PepT 1) also known as solute carrier family 15 member 1 (SLC15A1) is a protein that in humans is encoded by SLC15A1 gene.^[5]^[6] PepT 1 is a solute carrier for oligopeptides. It functions in renal oligopeptide reabsorption and in the intestines in a proton dependent way, hence acting like a cotransporter.^[7]

Function

SLC15A1is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs.^[5]^[7] Peptide transporter 1 functions in nutrient and drug transport have been studied using intestinal organoids.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000088386 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025557 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: SLC15A1 Solute carrier family 15 (oligopeptide transporter), member 1".
^ Liang R, Fei YJ, Prasad PD, Ramamoorthy S, Han H, Yang-Feng TL, et al. (March 1995). "Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization". J. Biol. Chem. 270 (12): 6456–63. doi:10.1074/jbc.270.12.6456. PMID 7896779.
^ ^a ^b Adibi SA (July 1997). "The oligopeptide transporter (Pept-1) in human intestine: biology and function". Gastroenterology. 113 (1): 332–40. doi:10.1016/S0016-5085(97)70112-4. PMID 9207295.
^ Zietek T, Rath E, Haller D, Daniel H (November 2015). "Intestinal organoids for assessing nutrient transport, sensing and incretin secretion". Scientific Reports. 5 (1): 16831. Bibcode:2015NatSR...516831Z. doi:10.1038/srep16831. PMC 4652176. PMID 26582215.
^ Zietek T, Giesbertz P, Ewers M, Reichart F, Weinmüller M, Demir IE, et al. (2020). "Organoids to Study Intestinal Nutrient Transport, Drug Uptake and Metabolism – Update to the Human Model and Expansion of Applications". Frontiers in Bioengineering and Biotechnology. 8: 577656. doi:10.3389/fbioe.2020.577656. PMC 7516017. PMID 33015026.

Adibi SA (2003). "Regulation of expression of the intestinal oligopeptide transporter (Pept-1) in health and disease". Am. J. Physiol. Gastrointest. Liver Physiol. 285 (5): G779–88. doi:10.1152/ajpgi.00056.2003. PMID 14561585.
Ganapathy ME, Brandsch M, Prasad PD, Ganapathy V, Leibach FH (1995). "Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2". J. Biol. Chem. 270 (43): 25672–7. doi:10.1074/jbc.270.43.25672. PMID 7592745.
Thamotharan M, Lombardo YB, Bawani SZ, Adibi SA (1997). "An active mechanism for completion of the final stage of protein degradation in the liver, lysosomal transport of dipeptides". J. Biol. Chem. 272 (18): 11786–90. doi:10.1074/jbc.272.18.11786. PMID 9115234.
Saito H, Motohashi H, Mukai M, Inui K (1997). "Cloning and characterization of a pH-sensing regulatory factor that modulates transport activity of the human H+/peptide cotransporter, PEPT1". Biochem. Biophys. Res. Commun. 237 (3): 577–82. doi:10.1006/bbrc.1997.7129. PMID 9299407.
Gonzalez DE, Covitz KM, Sadée W, Mrsny RJ (1998). "An oligopeptide transporter is expressed at high levels in the pancreatic carcinoma cell lines AsPc-1 and Capan-2". Cancer Res. 58 (3): 519–25. PMID 9458100.
Walker D, Thwaites DT, Simmons NL, Gilbert HJ, Hirst BH (1998). "Substrate upregulation of the human small intestinal peptide transporter, hPepT1". J. Physiol. 507 (3): 697–706. doi:10.1111/j.1469-7793.1998.697bs.x. PMC 2230834. PMID 9508831.
Ashida K, Katsura T, Motohashi H, Saito H, Inui K (2002). "Thyroid hormone regulates the activity and expression of the peptide transporter PEPT1 in Caco-2 cells". Am. J. Physiol. Gastrointest. Liver Physiol. 282 (4): G617–23. doi:10.1152/ajpgi.00344.2001. PMID 11897620.
Döring F, Martini C, Walter J, Daniel H (2002). "Importance of a small N-terminal region in mammalian peptide transporters for substrate affinity and function". J. Membr. Biol. 186 (2): 55–62. doi:10.1007/s00232-001-0135-9. PMID 11944083. S2CID 11211548.
Ford D, Howard A, Hirst BH (2003). "Expression of the peptide transporter hPepT1 in human colon: a potential route for colonic protein nitrogen and drug absorption". Histochem. Cell Biol. 119 (1): 37–43. doi:10.1007/s00418-002-0479-y. PMID 12548404. S2CID 7822041.
Neumann J, Brandsch M (2003). "Delta-aminolevulinic acid transport in cancer cells of the human extrahepatic biliary duct". J. Pharmacol. Exp. Ther. 305 (1): 219–24. doi:10.1124/jpet.102.046573. PMID 12649372. S2CID 34721079.
Sun BW, Zhao XC, Wang GJ, Li N, Li JS (2003). "Hormonal regulation of dipeptide transporter (PepT1) in Caco-2 cells with normal and anoxia/reoxygenation management". World J. Gastroenterol. 9 (4): 808–12. doi:10.3748/wjg.v9.i4.808. PMC 4611455. PMID 12679938.
Kulkarni AA, Haworth IS, Lee VH (2003). "Transmembrane segment 5 of the dipeptide transporter hPepT1 forms a part of the substrate translocation pathway". Biochem. Biophys. Res. Commun. 306 (1): 177–85. doi:10.1016/S0006-291X(03)00926-4. PMID 12788085.
Kulkarni AA, Haworth IS, Uchiyama T, Lee VH (2004). "Analysis of transmembrane segment 7 of the dipeptide transporter hPepT1 by cysteine-scanning mutagenesis". J. Biol. Chem. 278 (51): 51833–40. doi:10.1074/jbc.M308356200. PMID 14532279.
Uchiyama T, Kulkarni AA, Davies DL, Lee VH (2004). "Biophysical evidence for His57 as a proton-binding site in the mammalian intestinal transporter hPepT1". Pharm. Res. 20 (12): 1911–6. doi:10.1023/B:PHAM.0000008036.05892.e9. PMID 14725353. S2CID 43450358.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)

By group

SLC1–10

(1):	high affinity glutamate and neutral amino-acid transporter SLC1A1 2 3 4 5 6 7
(2):	facilitative GLUT transporter SLC2A1 2 3 4 5 6 7 8 9 10 11 12 13 14
(3):	heavy subunits of heterodimeric amino-acid transporters SLC3A1 2
(4):	bicarbonate transporter SLC4A1 2 3 4 5 6 7 8 9 10 11
(5):	sodium glucose cotransporter SLC5A1 2 3 4 5 6 7 8 9 10 11 12
(6):	sodium- and chloride- dependent sodium:neurotransmitter symporters SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A6 SLC6A7 SLC6A8 SLC6A9 SLC6A10 SLC6A11 SLC6A12 SLC6A13 SLC6A14 SLC6A15 SLC6A16 SLC6A17 SLC6A18 SLC6A19 SLC6A20
(7):	cationic amino-acid transporter/glycoprotein-associated SLC7A1 SLC7A2 SLC7A3 SLC7A4 glycoprotein-associated/light or catalytic subunits of heterodimeric amino-acid transporters SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC7A10 SLC7A11 SLC7A13 SLC7A14
(8):	Na⁺/Ca²⁺ exchanger SLC8A1 SLC8A2 SLC8A3
(9):	Na⁺/H⁺ exchanger SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A10 SLC9A11
(10):	sodium bile salt cotransport SLC10A1 SLC10A2 SLC10A3 SLC10A4 SLC10A5 SLC10A6 SLC10A7 10A1 10A2 10A3 10A7

SLC11–20

(11):	proton coupled metal ion transporter SLC11A1 SLC11A2 11A3
(12):	electroneutral cation-Cl cotransporter SLC12A1 SLC12A2 SLC12A3 SLC12A4 SLC12A5 SLC12A6 SLC12A7 SLC12A8 SLC12A9
(13):	human Na⁺-sulfate/carboxylate cotransporter SLC13A1 SLC13A2 SLC13A3 SLC13A4 SLC13A5
(14):	urea transporter SLC14A1 SLC14A2
(15):	proton oligopeptide cotransporter SLC15A1 SLC15A2 SLC15A3 SLC15A4
(16):	monocarboxylate transporter SLC16A1 SLC16A2 SLC16A3 SLC16A4 SLC16A5 SLC16A6 SLC16A7 SLC16A8 SLC16A9 SLC16A10 SLC16A11 SLC16A12 SLC16A13 SLC16A14
(17):	Vesicular glutamate transporter 1 SLC17A1 SLC17A2 SLC17A3 SLC17A4 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC17A9
(18):	vesicular monoamine transporter SLC18A1 SLC18A2 SLC18A3
(19):	folate/thiamine transporter SLC19A1 SLC19A2 SLC19A3
(20):	type III Na⁺-phosphate cotransporter SLC20A1 SLC20A2

SLC21–30

(21):	Organic anion-transporting polypeptide SLCO1A2 SLCO1B1 SLCO1B3 SLCO1B4 SLCO1C1 SLCO2A1 SLCO2B1 SLCO3A1 SLCO4A1 SLCO4C1 SLCO5A1(SLCO6A1)
(22):	organic cation/anion/zwitterion transporter SLC22A1 SLC22A2 SLC22A3 SLC22A4 SLC22A5 SLC22A6 SLC22A7 SLC22A8 SLC22A9 SLC22A10 SLC22A11 SLC22A12 SLC22A13 SLC22A14 SLC22A15 SLC22A16 SLC22A17 SLC22A18 SLC22A19 SLC22A20
(23):	Na+-dependent ascorbic acid transporter SLC23A1 SLC23A2 SLC23A3 SLC23A4
(24):	Na⁺/(Ca²⁺-K⁺) exchanger SLC24A1 SLC24A2 SLC24A3 SLC24A4 SLC24A5 SLC24A6
(25):	mitochondrial carrier SLC25A1 SLC25A2 SLC25A3 SLC25A4 SLC25A5 SLC25A6 SLC25A7 SLC25A8 SLC25A9 SLC25A10 SLC25A11 SLC25A12 SLC25A13 SLC25A14 SLC25A15 SLC25A16 SLC25A17 SLC25A18 SLC25A19 SLC25A20 SLC25A21 SLC25A22 SLC25A23 SLC25A24 SLC25A25 SLC25A26 SLC25A27 SLC25A28 SLC25A29 SLC25A30 SLC25A31 SLC25A32 SLC25A33 SLC25A34 SLC25A35 SLC25A36 SLC25A37 SLC25A38 SLC25A39 SLC25A40 SLC25A41 SLC25A42 SLC25A43 SLC25A44 SLC25A45 SLC25A46
(26):	multifunctional anion exchanger SLC26A1 SLC26A2 SLC26A3 SLC26A4 SLC26A5 SLC26A6 SLC26A7 SLC26A8 SLC26A9 SLC26A10 SLC26A11
(27):	fatty acid transport proteins SLC27A1 SLC27A2 SLC27A3 SLC27A4 SLC27A5 SLC27A6
(28):	Na⁺-coupled nucleoside transport (SLC28A1 SLC28A2 SLC28A3
(29):	facilitative nucleoside transporter SLC29A1 SLC29A2 SLC29A3 SLC29A4
(30):	zinc efflux SLC30A1 SLC30A2 SLC30A3 SLC30A4 SLC30A5 SLC30A6 SLC30A7 SLC30A8 SLC30A9 SLC30A10

SLC31–40

(31):	copper transporter SLC31A1
(32):	Vesicular glutamate transporter 1 SLC32A1
(33):	Acetyl-CoA transporter SLC33A1
(34):	type II Na⁺-phosphate cotransporter SLC34A1 SLC34A2 SLC34A3
(35):	nucleoside-sugar transporter SLC35A1 SLC35A2 SLC35A3 SLC35A4 SLC35A5 SLC35B1 SLC35B2 SLC35B3 SLC35B4 SLC35C1 SLC35C2 SLC35D1 SLC35D2 SLC35D3 SLC35E1 SLC35E2 SLC35E3 SLC35E4
(36):	proton-coupled amino-acid transporter SLC36A1 SLC36A2 SLC36A3 SLC36A436A2
(37):	sugar-phosphate/phosphate exchanger SLC37A1 SLC37A2 SLC37A3 SLC37A4
(38):	System A & N, sodium-coupled neutral amino-acid transporter SLC38A1 SLC38A2 SLC38A3 SLC38A4 SLC38A5 SLC38A6 SLC38A10
(39):	metal ion transporter SLC39A1 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 SLC39A9 SLC39A10 SLC39A11 SLC39A12 SLC39A13 SLC39A14
(40):	basolateral iron transporter SLC40A1

SLC41–48

(41):	Magnesium transporter E SLC41A1 SLC41A2 SLC41A3
(42):	Ammonia transporter RhAG RhBG RhCG
(43):	Na⁺-independent, system-L like amino-acid transporter SLC43A1 SLC43A2 SLC43A3
(44):	Choline-like transporter SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5
(45):	Putative sugar transporter SLC45A1 SLC45A2 SLC54A3 SLC45A4
(46):	Folate transporter SLC46A1 SLC46A2
(47):	multidrug and toxin extrusion SLC47A1 SLC47A2
(48):	Heme transporter

SLCO1–4
O1A2 O1B1 O1B3 O2B1 O431 O4A1

Ion pumps

Symporter, Cotransporter	Na⁺/K⁺,Cl⁻ Na⁺/P_i3 Na⁺/Cl⁻ Na⁺/glucose Na⁺/I⁻ Cl⁻/K⁺ 4 5
Antiporter (exchanger)	Na⁺/H⁺ Na⁺/Ca²⁺ Na⁺/(Ca²⁺-K⁺) - Cl⁻/HCO⁻ ₃ (Band 3) Cl⁻-formate Cl⁻-oxalate