PRPSAP1

Protein-coding gene in the species Homo sapiens

PRPSAP1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2C4K

Identifiers

Aliases

PRPSAP1, PAP39, phosphoribosyl pyrophosphate synthetase-associated protein 1, phosphoribosyl pyrophosphate synthetase associated protein 1

External IDs

OMIM: 601249; MGI: 1915013; HomoloGene: 55687; GeneCards: PRPSAP1; OMA:PRPSAP1 - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q25.1	Start	76,309,478 bp^[1]
Band	17q25.1	End	76,384,521 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 E2	Start	116,361,671 bp^[2]
Band	11\|11 E2	End	116,385,028 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

parotid gland

right lobe of thyroid gland

gonad

minor salivary glands

left lobe of thyroid gland

left testis

right testis

right lung

ventricular zone

right adrenal cortex

Top expressed in

Paneth cell

internal carotid artery

epithelium of lens

external carotid artery

duodenum

crypt of lieberkuhn of small intestine

endothelial cell of lymphatic vessel

left lobe of liver

condyle

jejunum

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	enzyme inhibitor activity ribose phosphate diphosphokinase activity magnesium ion binding protein binding identical protein binding enzyme regulator activity
Cellular component	ribose phosphate diphosphokinase complex cytoplasm
Biological process	nucleotide biosynthetic process nucleobase-containing compound metabolic process negative regulation of catalytic activity 5-phosphoribose 1-diphosphate biosynthetic process purine nucleotide biosynthetic process regulation of catalytic activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5635


67763

Ensembl


ENSG00000161542


ENSMUSG00000015869

UniProt


Q14558


Q9D0M1

RefSeq (mRNA)


NM_002766 NM_001330503 NM_001366236


NM_026364

RefSeq (protein)


NP_001317432 NP_002757 NP_001353165


NP_080640 NP_001391595 NP_001391596 NP_001391597 NP_001391598

Location (UCSC)

Chr 17: 76.31 – 76.38 Mb

Chr 11: 116.36 – 116.39 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Phosphoribosyl pyrophosphate synthetase-associated protein 1 is an enzyme that in humans is encoded by the PRPSAP1 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000161542 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015869 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishizuka T, Ahmad I, Kita K, Sonoda T, Ishijima S, Sawa K, Suzuki N, Tatibana M (Jan 1997). "The human phosphoribosylpyrophosphate synthetase-associated protein 39 gene (PRPSAP1) is located in the chromosome region 17q24-q25". Genomics. 33 (2): 332–4. doi:10.1006/geno.1996.0207. PMID 8660991.
^ "Entrez Gene: PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1".

Tatibana M, Kita K, Taira M, et al. (1995). "Mammalian phosphoribosyl-pyrophosphate synthetase". Adv. Enzyme Regul. 35: 229–49. doi:10.1016/0065-2571(94)00017-W. PMID 7572345.
Kita K, Ishizuka T, Ishijima S, et al. (1994). "A novel 39-kDa phosphoribosylpyrophosphate synthetase-associated protein of rat liver. Cloning, high sequence similarity to the catalytic subunits, and a negative regulatory role". J. Biol. Chem. 269 (11): 8334–40. doi:10.1016/S0021-9258(17)37198-3. PMID 8132556.
Ishizuka T, Kita K, Sonoda T, et al. (1996). "Cloning and sequencing of human complementary DNA for the phosphoribosylpyrophosphate synthetase-associated protein 39". Biochim. Biophys. Acta. 1306 (1): 27–30. doi:10.1016/0167-4781(96)00030-9. PMID 8611620.
Ishijima S, Asai T, Kita K, et al. (1997). "Partial reconstitution of mammalian phosphoribosylpyrophosphate synthetase in Escherichia coli cells. Coexpression of catalytic subunits with the 39-kDa associated protein leads to formation of soluble multimeric complexes of various compositions". Biochim. Biophys. Acta. 1342 (1): 28–36. doi:10.1016/s0167-4838(97)00077-0. PMID 9366267.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.