MMPIP
Chemical compound
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CompTox Dashboard (EPA) |
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Chemical and physical data | |
Formula | C19H19N3O3 |
Molar mass | 337.379 g·mol−1 |
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MMPIP is a drug used in scientific research that acts as a selective antagonist for the metabotropic glutamate receptor subtype mGluR7.[1] This receptor subtype appears to be involved in the downstream response to cocaine in the brain.[2]
References
- ^ Suzuki G, Tsukamoto N, Fushiki H, Kawagishi A, Nakamura M, Kurihara H, Mitsuya M, Ohkubo M, Ohta H (October 2007). "In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists". The Journal of Pharmacology and Experimental Therapeutics. 323 (1): 147–56. doi:10.1124/jpet.107.124701. PMID 17609420. S2CID 10402176.
- ^ Li X, Li J, Peng XQ, Spiller K, Gardner EL, Xi ZX (June 2009). "Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanism". Neuropsychopharmacology. 34 (7): 1783–96. doi:10.1038/npp.2008.236. PMC 3739975. PMID 19158667.
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Metabotropic glutamate receptor modulators
mGluR1Tooltip Metabotropic glutamate receptor 1 |
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mGluR5Tooltip Metabotropic glutamate receptor 5 |
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mGluR2Tooltip Metabotropic glutamate receptor 2 |
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mGluR3Tooltip Metabotropic glutamate receptor 3 |
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mGluR4Tooltip Metabotropic glutamate receptor 4 |
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mGluR6Tooltip Metabotropic glutamate receptor 6 |
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mGluR7Tooltip Metabotropic glutamate receptor 7 | |
mGluR8Tooltip Metabotropic glutamate receptor 8 |
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See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Glutamate metabolism/transport modulators
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