MARVELD2

Protein-coding gene in the species Homo sapiens
MARVELD2
Identifiers
AliasesMARVELD2, DFNB49, MARVD2, MRVLDC2, Tric, MARVEL domain containing 2
External IDsOMIM: 610572; MGI: 2446166; HomoloGene: 27037; GeneCards: MARVELD2; OMA:MARVELD2 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for MARVELD2
Genomic location for MARVELD2
Band5q13.2Start69,415,065 bp[1]
End69,444,330 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for MARVELD2
Genomic location for MARVELD2
Band13|13 D1Start100,732,465 bp[2]
End100,753,479 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • islet of Langerhans

  • duodenum

  • liver

  • rectum

  • thyroid gland

  • left lobe of thyroid gland

  • right lobe of thyroid gland

  • right lobe of liver

  • body of pancreas

  • kidney
Top expressed in
  • saccule

  • otic placode

  • Hindgut

  • urothelium

  • conjunctival fornix

  • medullary collecting duct

  • Paneth cell

  • ileum

  • secondary oocyte

  • large intestine
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • integral component of membrane
  • plasma membrane
  • basolateral plasma membrane
  • apical plasma membrane
  • cytoplasmic vesicle
  • membrane
  • tricellular tight junction
  • bicellular tight junction
  • cell junction
  • paranodal junction
  • Schmidt-Lanterman incisure
Biological process
  • establishment of endothelial barrier
  • cell-cell junction organization
  • sensory perception of sound
  • bicellular tight junction assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

153562

218518

Ensembl

ENSG00000274671
ENSG00000152939

ENSMUSG00000021636

UniProt

Q8N4S9

Q3UZP0

RefSeq (mRNA)

NM_001038603
NM_001244734
NM_144724

NM_001038602
NM_178410

RefSeq (protein)

NP_001033692
NP_001231663

NP_001033691
NP_848497

Location (UCSC)Chr 5: 69.42 – 69.44 MbChr 13: 100.73 – 100.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MARVEL domain-containing protein 2 is a protein that in humans is encoded by the MARVELD2 gene.[5][6]


References

  1. ^ a b c ENSG00000152939 GRCh38: Ensembl release 89: ENSG00000274671, ENSG00000152939 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021636 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Riazuddin S, Ahmed ZM, Fanning AS, Lagziel A, Kitajiri S, Ramzan K, Khan SN, Chattaraj P, Friedman PL, Anderson JM, Belyantseva IA, Forge A, Riazuddin S, Friedman TB (Dec 2006). "Tricellulin is a tight-junction protein necessary for hearing". Am J Hum Genet. 79 (6): 1040–51. doi:10.1086/510022. PMC 1698716. PMID 17186462.
  6. ^ "Entrez Gene: MARVELD2 MARVEL domain containing 2".

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Ikenouchi J, Furuse M, Furuse K, et al. (2006). "Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells". J. Cell Biol. 171 (6): 939–45. doi:10.1083/jcb.200510043. PMC 2171318. PMID 16365161.
  • Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
  • Ramzan K, Shaikh RS, Ahmad J, et al. (2005). "A new locus for nonsyndromic deafness DFNB49 maps to chromosome 5q12.3-q14.1". Hum. Genet. 116 (1–2): 17–22. doi:10.1007/s00439-004-1205-8. PMID 15538632. S2CID 39267757.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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