Luliconazole

Chemical compound

Pharmacokinetic dataProtein binding>99%^[1]Identifiers

(2E)-[(4R)-4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene](1H-imidazol-1-yl)acetonitrile

CAS Number

PubChem CID

ChemSpider

UNII

CompTox Dashboard (EPA)

Chemical and physical dataFormulaC₁₄H₉Cl₂N₃S₂Molar mass354.27 g·mol⁻¹3D model (JSmol)

InChI

InChI=1S/C14H9Cl2N3S2/c15-9-1-2-10(11(16)5-9)13-7-20-14(21-13)12(6-17)19-4-3-18-8-19/h1-5,8,13H,7H2/b14-12+/t13-/m0/s1
Key:YTAOBBFIOAEMLL-REQDGWNSSA-N

Luliconazole, trade names Luzu among others, is an imidazole antifungal medication.^[2] As a 1% topical cream, It is indicated for the treatment of athlete's foot, jock itch, and ringworm caused by dermatophytes such as Trichophyton rubrum, Microsporum gypseum,^[3] and Epidermophyton floccosum.^[1]

References

^ ^a ^b "LUZU (luliconazole) Cream, 1%. Full Prescribing Information" (PDF). Valeant Pharmaceuticals North America LLC. Retrieved 1 October 2015.
^ Gupta AK, Daigle D (2016). "A critical appraisal of once-daily topical luliconazole for the treatment of superficial fungal infections". Infection and Drug Resistance. 9: 1–6. doi:10.2147/IDR.S61998. PMC 4723097. PMID 26848272.
^ "FDA approves luliconazole for tinea pedis". November 19, 2013. Archived from the original on 16 January 2014. Retrieved 14 January 2014.

Wall/
membrane

Ergosterol
inhibitors

Azoles (lanosterol 14α-
demethylase inhibitors)

Imidazoles	Topical: bifonazole^‡ butoconazole chlormidazole^‡ climbazole clotrimazole^# croconazole^‡ eberconazole econazole fenticonazole^‡ flutrimazole isoconazole ketoconazole luliconazole miconazole^# neticonazole^‡ omoconazole^‡ oxiconazole sertaconazole sulconazole tioconazole Systemic: ketoconazole
Triazoles	Topical: efinaconazole fluconazole^# terconazole Systemic: fluconazole^# fosfluconazole fosravuconazole hexaconazole^‡ isavuconazole itraconazole^# oteseconazole posaconazole voriconazole^# Unknown: albaconazole^‡ ravuconazole^†
Thiazoles	Topical: abafungin^‡

Allylamines	Topical: naftifine terbinafine Systemic: terbinafine
Benzylamines	Topical: butenafine

Others

Intracellular

Pyrimidine analogues/ thymidylate synthase inhibitors	Systemic: flucytosine^#
Mitotic inhibitors	Systemic: griseofulvin^#
Aminoacyl tRNA synthetase inhibitors	Topical: tavaborole