GV (nerve agent)

GV
Ball-and-stick model of GV
Skeletal formula of GV
Names
IUPAC name
2-(Dimethylamino)ethyl N,N-dimethylphosphoramidofluoridate
Other names
EA-5365
Identifiers
CAS Number
  • 141102-74-1 ☒N
3D model (JSmol)
  • Interactive image
ChemSpider
  • 112656 checkY
PubChem CID
  • 132333
CompTox Dashboard (EPA)
  • DTXSID30930987 Edit this at Wikidata
InChI
  • InChI=1S/C6H16FN2OP/c1-8(2)5-6-11(7,10)9(3)4/h5-6H2,1-4H3 checkY
    Key: JJHAGEZAXYOCMC-UHFFFAOYSA-N checkY
  • InChI=1/C6H16FN2OP/c1-8(2)5-6-11(7,10)9(3)4/h5-6H2,1-4H3
    Key: JJHAGEZAXYOCMC-UHFFFAOYAS
  • FP(=O)(N(C)C)CCN(C)C
Properties
Chemical formula
C6H16FN2O2P
Molar mass 198.176 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references
Chemical compound

GV (IUPAC name: 2-(Dimethylamino)ethyl N,N-dimethylphosphoramidofluoridate), also known as EA-5365, is an organophosphate nerve agent. GV is a part of a new series of nerve agents with properties similar to both the "G-series" and "V-series". It is a potent acetylcholinesterase inhibitor with properties similar to other nerve agents, being a highly poisonous vapour. Treatment for poisoning with GV involves drugs such as atropine, benactyzine, obidoxime, and HI-6.[1][2]

See also

References

  1. ^ Fusek J, Bajgar J (1994). "Treatment of intoxication with GV compound in laboratory rats". Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 37 (2): 57–62. PMID 7784799.
  2. ^ Kassa J, Bajgar J (1996). "Therapeutic efficacy of obidoxime or HI-6 with atropine against intoxication with some nerve agents in mice". Acta Medica (Hradec Kralove). 39 (1): 27–30. PMID 9106387.

External links

Wikimedia Commons has media related to GV nerve agent.
  • Harvey SP, Cheng TC (2002). "Identification, Purification, and Partial Characterization of the GV-Degrading Enzyme from ATCC # 29660 Alteromonas undina". Aberdeen Proving Ground: Edgewood. OCLC 74239874. Report ECBC-TR-229. Archived from the original (pdf) on 2013-09-09. Retrieved 2013-09-09.
  • Bajgar J (1998). "Some Toxic Chemicals as Potential Chemical Warfare Agents - The Threat for the Future?". ASA Newsletter. 1998 (6).
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Enzyme
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ChATTooltip Choline acetyltransferase
  • Inhibitors: 1-(-Benzoylethyl)pyridinium
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AChETooltip Acetylcholinesterase
BChETooltip Butyrylcholinesterase
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CHTTooltip Choline transporter
VAChTTooltip Vesicular acetylcholine transporter
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(modulators)
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  • SNAP-25Tooltip Synaptosomal-associated protein 25 inactivators: Botulinum toxin (A, C, E)
  • VAMPTooltip Vesicle-associated membrane protein inactivators: Botulinum toxin (B, D, F, G)
Enhancers
See also
Receptor/signaling modulators
Muscarinic acetylcholine receptor modulators
Nicotinic acetylcholine receptor modulators
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