GPR89B

Protein-coding gene in the species Homo sapiens
GPR89B
Identifiers
AliasesGPR89B, GPHR, GPR89, GPR89C, SH120, UNQ192, G protein-coupled receptor 89B
External IDsOMIM: 612806; MGI: 1914799; HomoloGene: 9475; GeneCards: GPR89B; OMA:GPR89B - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for GPR89B
Genomic location for GPR89B
Band1q21.2Start147,928,393 bp[1]
End147,993,592 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for GPR89B
Genomic location for GPR89B
Band3|3 F2.1Start96,775,597 bp[2]
End96,812,662 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • duodenum

  • corpus callosum

  • Achilles tendon

  • human kidney

  • body of pancreas

  • granulocyte

  • cerebellar cortex

  • cerebellar hemisphere

  • right lobe of liver
Top expressed in
  • spermatocyte

  • lacrimal gland

  • jejunum

  • otic vesicle

  • ileum

  • saccule

  • intestinal epithelium

  • interventricular septum

  • epithelium of small intestine

  • right lobe of liver
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • voltage-gated anion channel activity
  • signal transducer activity
  • voltage-gated ion channel activity
Cellular component
  • integral component of membrane
  • Golgi cisterna membrane
  • Golgi-associated vesicle membrane
  • Golgi membrane
  • Golgi apparatus
  • membrane
Biological process
  • protein transport
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • regulation of ion transmembrane transport
  • ion transport
  • intracellular pH reduction
  • signal transduction
  • regulation of anion transmembrane transport
  • transport
  • ion transmembrane transport
  • inorganic anion transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51463

67549

Ensembl

ENSG00000188092

ENSMUSG00000028096

UniProt

P0CG08

Q8BS95

RefSeq (mRNA)
NM_001097616
NM_001350180
NM_001350181
NM_001350182
NM_001350183

NM_001350184
NM_016334

NM_026229

RefSeq (protein)
NP_001091081
NP_001091082
NP_001337109
NP_001337110
NP_001337111

NP_001337112
NP_001337113
NP_057418
NP_001337109
NP_001337110
NP_001337111
NP_001337112
NP_001337113
NP_057418
NP_001091081
NP_001091082

NP_080505

Location (UCSC)Chr 1: 147.93 – 147.99 MbChr 3: 96.78 – 96.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein GPR89 is a protein that in humans is encoded by the GPR89B gene.[5][6]


Related gene problems

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188092 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028096 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  6. ^ "Entrez Gene: GPR89A G protein-coupled receptor 89A".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.


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