GABARAPL2

Protein-coding gene in the species Homo sapiens

GABARAPL2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
4CO7

Identifiers

Aliases

GABARAPL2, ATG8, ATG8C, GATE-16, GATE16, GEF-2, GEF2, GABA type A receptor associated protein like 2

External IDs

OMIM: 607452; MGI: 1890602; HomoloGene: 68550; GeneCards: GABARAPL2; OMA:GABARAPL2 - orthologs

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16q23.1	Start	75,566,375 bp^[1]
Band	16q23.1	End	75,577,881 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8\|8 E1	Start	112,667,335 bp^[2]
Band	8\|8 E1	End	112,680,244 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

pons

Brodmann area 46

cerebellar vermis

internal globus pallidus

superior vestibular nucleus

hypothalamus

subthalamic nucleus

spinal cord

C1 segment

nucleus accumbens

Top expressed in

hypothalamus

neural tube

cerebellar cortex

ganglionic eminence

blastocyst

morula

dentate gyrus of hippocampal formation granule cell

right kidney

Cortex of frontal lobe

bone marrow

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	GABA receptor binding microtubule binding ATPase binding protein binding beta-tubulin binding SNARE binding ubiquitin protein ligase binding
Cellular component	cytoplasm Golgi apparatus Golgi membrane intracellular anatomical structure autophagosome autophagosome membrane cytoplasmic vesicle cytosol
Biological process	positive regulation of ATP-dependent activity autophagy protein transport negative regulation of proteasomal protein catabolic process intra-Golgi vesicle-mediated transport macroautophagy autophagosome maturation autophagosome assembly autophagy of mitochondrion cellular response to nitrogen starvation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


11345


93739

Ensembl


ENSG00000034713


ENSMUSG00000031950

UniProt


P60520


P60521

RefSeq (mRNA)


NM_007285


NM_026693

RefSeq (protein)


NP_009216


NP_080969

Location (UCSC)

Chr 16: 75.57 – 75.58 Mb

Chr 8: 112.67 – 112.68 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Gamma-aminobutyric acid receptor-associated protein-like 2 is a protein that in humans is encoded by the GABARAPL2 gene.^[5]^[6]

Interactions

GABARAPL2 has been shown to interact with ULK1,^[7] ATG4B,^[8]^[9] and FAM134B.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000034713 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031950 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Xin Y, Yu L, Chen Z, Zheng L, Fu Q, Jiang J, Zhang P, Gong R, Zhao S (Jun 2001). "Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein". Genomics. 74 (3): 408–13. doi:10.1006/geno.2001.6555. PMID 11414770.
^ "Entrez Gene: GABARAPL2 GABA(A) receptor-associated protein-like 2".
^ Okazaki N, Yan J, Yuasa S, Ueno T, Kominami E, Masuho Y, Koga H, Muramatsu M (Dec 2000). "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation". Brain Research. Molecular Brain Research. 85 (1–2): 1–12. doi:10.1016/S0169-328X(00)00218-7. PMID 11146101.
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
^ Khaminets, Aliaksandr; Heinrich, Theresa; Mari, Muriel; Grumati, Paolo; Huebner, Antje K.; Akutsu, Masato; Liebmann, Lutz; Stolz, Alexandra; Nietzsche, Sandor (2015-06-18). "Regulation of endoplasmic reticulum turnover by selective autophagy". Nature. 522 (7556): 354–358. Bibcode:2015Natur.522..354K. doi:10.1038/nature14498. ISSN 0028-0836. PMID 26040720. S2CID 4449106.

Rohwer A, Kittstein W, Marks F, Gschwendt M (Jul 1999). "Cloning, expression and characterization of an A6-related protein". European Journal of Biochemistry. 263 (2): 518–25. doi:10.1046/j.1432-1327.1999.00537.x. PMID 10406962.
Sagiv Y, Legesse-Miller A, Porat A, Elazar Z (Apr 2000). "GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28". The EMBO Journal. 19 (7): 1494–504. doi:10.1093/emboj/19.7.1494. PMC 310219. PMID 10747018.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Okazaki N, Yan J, Yuasa S, Ueno T, Kominami E, Masuho Y, Koga H, Muramatsu M (Dec 2000). "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation". Brain Research. Molecular Brain Research. 85 (1–2): 1–12. doi:10.1016/S0169-328X(00)00218-7. PMID 11146101.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Tanida I, Tanida-Miyake E, Nishitani T, Komatsu M, Yamazaki H, Ueno T, Kominami E (Mar 2002). "Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs". Biochemical and Biophysical Research Communications. 292 (1): 256–62. doi:10.1006/bbrc.2002.6645. PMID 11890701.
Scherz-Shouval R, Sagiv Y, Shorer H, Elazar Z (Apr 2003). "The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A". The Journal of Biological Chemistry. 278 (16): 14053–8. doi:10.1074/jbc.M212108200. PMID 12473658.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Sou YS, Tanida I, Komatsu M, Ueno T, Kominami E (Feb 2006). "Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16". The Journal of Biological Chemistry. 281 (6): 3017–24. doi:10.1074/jbc.M505888200. PMID 16303767.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.