Fructose-bisphosphatase 2

Protein-coding gene in the species Homo sapiens
FBP2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3IFA, 3IFC, 4HE0, 4HE1, 4HE2, 5ET7, 5ET5, 5ET6

Identifiers
AliasesFBP2, fructose-bisphosphatase 2, CORLK
External IDsOMIM: 603027; MGI: 95491; HomoloGene: 55784; GeneCards: FBP2; OMA:FBP2 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for FBP2
Genomic location for FBP2
Band9q22.32Start94,558,720 bp[1]
End94,593,824 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for FBP2
Genomic location for FBP2
Band13|13 B3Start62,984,691 bp[2]
End63,006,236 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • biceps brachii

  • vastus lateralis muscle

  • triceps brachii muscle

  • gastrocnemius muscle

  • thoracic diaphragm

  • body of tongue

  • deltoid muscle

  • body of stomach

  • secondary oocyte

  • fundus
Top expressed in
  • ileum

  • duodenum

  • jejunum

  • morula

  • blastocyst

  • intestinal epithelium

  • intestinal villus

  • Paneth cell

  • left colon

  • crypt of lieberkuhn of small intestine
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • phosphoric ester hydrolase activity
  • catalytic activity
  • hydrolase activity
  • protein binding
  • metal ion binding
  • phosphatase activity
  • fructose 1,6-bisphosphate 1-phosphatase activity
  • identical protein binding
Cellular component
  • cytoplasm
  • cell junction
  • Z disc
  • extracellular exosome
  • nucleus
  • nucleoplasm
  • cytosol
  • plasma membrane
Biological process
  • fructose metabolic process
  • metabolism
  • dephosphorylation
  • sucrose biosynthetic process
  • fructose 6-phosphate metabolic process
  • gluconeogenesis
  • fructose 1,6-bisphosphate metabolic process
  • carbohydrate metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8789

14120

Ensembl

ENSG00000130957

ENSMUSG00000021456

UniProt

O00757

P70695

RefSeq (mRNA)

NM_003837

NM_007994

RefSeq (protein)

NP_003828

NP_032020

Location (UCSC)Chr 9: 94.56 – 94.59 MbChr 13: 62.98 – 63.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fructose-bisphosphatase 2 is an enzyme that in humans is encoded by the FBP2 gene. [5]

Function

This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 2,6-bisphosphate to fructose 6-phosphate and inorganic phosphate.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130957 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021456 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Fructose-bisphosphatase 2". Retrieved 2018-09-14.
  6. ^ Lee T, Bhushan B, Sochat M (January 2020). first aid for the USMLE Step 1 (Thirtieth ed.). USA: Mc GrawHill. p. 76. ISBN 9781260462043.

Further reading

  • Rakus D, Maciaszczyk E, Wawrzycka D, Ułaszewski S, Eschrich K, Dzugaj A (October 2005). "The origin of the high sensitivity of muscle fructose 1,6-bisphosphatase towards AMP". FEBS Letters. 579 (25): 5577–5581. doi:10.1016/j.febslet.2005.09.021. PMID 16213487. S2CID 6931830.
  • Gizak A, Maciaszczyk E, Dzugaj A, Eschrich K, Rakus D (July 2008). "Evolutionary conserved N-terminal region of human muscle fructose 1,6-bisphosphatase regulates its activity and the interaction with aldolase". Proteins. 72 (1): 209–216. doi:10.1002/prot.21909. PMID 18214967. S2CID 21403418.
  • Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A (December 2010). "Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study". Mutation Research. 694 (1–2): 13–19. doi:10.1016/j.mrfmmm.2010.08.006. PMID 20800603.
  • Li H, Wang J, Xu H, Xing R, Pan Y, Li W, et al. (September 2013). "Decreased fructose-1,6-bisphosphatase-2 expression promotes glycolysis and growth in gastric cancer cells". Molecular Cancer. 12 (1): 110. doi:10.1186/1476-4598-12-110. PMC 3849177. PMID 24063558.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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