Calpain-8

Protein-coding gene in the species Homo sapiens
CAPN8
Identifiers
AliasesCAPN8, nCL-2, calpain 8
External IDsMGI: 2181366; HomoloGene: 15643; GeneCards: CAPN8; OMA:CAPN8 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CAPN8
Genomic location for CAPN8
Band1q41Start223,538,007 bp[1]
End223,665,723 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for CAPN8
Genomic location for CAPN8
Band1|1 H5Start182,392,572 bp[2]
End182,459,917 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pylorus

  • gastric mucosa

  • pancreatic ductal cell

  • rectum

  • upper lobe of left lung

  • body of stomach

  • gallbladder

  • minor salivary glands

  • right lung

  • fundus
Top expressed in
  • pyloric antrum

  • epithelium of stomach

  • mucous cell of stomach

  • hair follicle

  • lip

  • duodenum

  • skin of abdomen

  • left colon

  • trachea

  • jejunum
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • peptidase activity
  • hydrolase activity
  • cysteine-type peptidase activity
  • metal ion binding
  • calcium ion binding
  • calcium-dependent cysteine-type endopeptidase activity
Cellular component
  • Golgi apparatus
  • intracellular anatomical structure
  • cytoplasm
Biological process
  • proteolysis
  • digestion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

388743

170725

Ensembl

ENSG00000203697

ENSMUSG00000038599

UniProt

A6NHC0
A3QK37

Q91VA3

RefSeq (mRNA)

NM_001143962

NM_001145806
NM_130890

RefSeq (protein)

NP_001137434

NP_001139278
NP_570960

Location (UCSC)Chr 1: 223.54 – 223.67 MbChr 1: 182.39 – 182.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calpain-8 is a protein in humans that is encoded by the CAPN8 gene.[5] [6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000203697 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038599 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "CAPN8 - Calpain-8 - Homo sapiens (Human) - CAPN8 gene & protein". www.uniprot.org. Retrieved 18 May 2022.
  6. ^ "Entrez Gene: Calpain 8". Retrieved 2012-12-16.

Further reading


  • v
  • t
  • e